SB-242235
| Synonyms: SB242235; SB 242235; SB242235 |
| CAS NO : 193746-75-7 |
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| Molecular Formula: C18H17N5O3 |
| Molecular Weight: 351.36 |
| Purity: 98% |
| Solubility: In DMSO |
| Storage: -20°C |
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Remarks:SB-242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases such as autoimmune or inflammatory diseases. SB-242235 demonstrates generally favourable pharmacokinetic properties. Systemic plasma clearance was high in rat, but in the non-rodent species SB-242235 demonstrated low to moderate clearance with plasma half-lives > 4h. Oral bioavailability in each preclinical species was high. In rat and monkey, SB-242235 demonstrated non-linear elimination kinetics that manifested as a decrease in clearance with increasing dose and apparent oral bioavailability > 100% at high oral doses. Furthermore, SB-242235 displayed concentration-dependent plasma protein binding over a concentration range of 1000-10,000 ng ml(-1). 3. In conclusion, SB-242235 demonstrates high oral bioavailability across the major preclinical species, and may thus be a useful tool compound for investigation of the role of p38 inhibition in various disease states.
Quality Control
H-NMR,C-NMR,LC-MS,HPLC. |
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